Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Get Citations Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0234361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0518 (Electronic) Linking ISSN: 00107824 NLM ISO Abbreviation: Contraception Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Elsevier
      Original Publication: Los Altos, Calif., Geron-X.
    • Subject Terms:
      Misoprostol*/therapeutic use ; Analgesics, Non-Narcotic*/therapeutic use; Pregnancy ; Female ; Humans ; Dextromethorphan/therapeutic use ; Double-Blind Method ; Analgesics/therapeutic use ; Pain/drug therapy ; Analgesics, Opioid/therapeutic use ; Pain, Postoperative/drug therapy
    • Abstract:
      Objectives: To evaluate efficacy and satisfaction of dextromethorphan as a non-narcotic adjuvant to current analgesic regimens for medication abortion.
      Study Design: We conducted a randomized, double-blinded, placebo-controlled trial. We randomized eligible participants (N = 156) 1:1 to adjunctively take dextromethorphan (loading dose 60 mg and two subsequent 30 mg doses at 2 and 5 hours after misoprostol administration) or placebo combined with usual-care nonsteroidal anti-inflammatory medications ± opioids for pain. Participants reported pain scores and satisfaction using a secure texting application at 2, 5, 8, and 24 hours after misoprostol administration. Our primary outcome was worst pain score and total analgesic use.
      Results: Baseline demographics of enrolled participants were similar between randomization arms. Worst pain scores for participants receiving dextromethorphan versus placebo (8.0 vs 7.0, p = 0.06) did not differ. Total milligram usage of ibuprofen (800 mg vs 610 mg, p =.62), acetaminophen (1000 mg vs 1300 mg, p = 0.62), and opioids (10 mg vs 15 mg, p = 0.51) did not differ between the randomization groups. Participants randomized to placebo were significantly more likely to be satisfied with their pain control (91% vs 75%, p = 0.02).
      Conclusion: Dextromethorphan used adjunctively with standard analgesics did not reduce pain associated with medication abortion. Participants who received dextromethorphan reported decreased satisfaction with their pain control.
      Implications: Dextromethorphan used adjunctively with commonly used analgesic regimens did not reduce medication abortion associated pain. Many participants did not use analgesics as counseled, and nearly 25% used no analgesia during medication abortion.
      (Copyright © 2022 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Abortion; Analgesia; Dextromethorphan; Medication abortion; Pain
    • Molecular Sequence:
      ClinicalTrials.gov NCT03480009
    • Accession Number:
      7355X3ROTS (Dextromethorphan)
      0E43V0BB57 (Misoprostol)
      0 (Analgesics)
      0 (Analgesics, Opioid)
      0 (Analgesics, Non-Narcotic)
    • Publication Date:
      Date Created: 20221104 Date Completed: 20230110 Latest Revision: 20230215
    • Publication Date:
      20230216
    • Accession Number:
      10.1016/j.contraception.2022.10.010
    • Accession Number:
      36332661
  • Citations
    • ABNT:
      FERGUSON, G. P. et al. Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial. Contraception, [s. l.], v. 118, p. 109908, 2023. DOI 10.1016/j.contraception.2022.10.010. Disponível em: https://ezproxy.mscc.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=36332661. Acesso em: 1 jun. 2023.
    • AMA 11th Edition:
      Ferguson GP, Achilles SL, Meyn LA, et al. Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial. Contraception. 2023;118:109908. doi:10.1016/j.contraception.2022.10.010
    • APA 7th Edition:
      Ferguson, G. P., Achilles, S. L., Meyn, L. A., Krajewski, C. M., Chappell, C. A., Vinekar, K., & Chen, B. A. (2023). Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial. Contraception, 118, 109908. https://doi.org/10.1016/j.contraception.2022.10.010
    • Chicago 17th Edition:
      Ferguson, Grace P, Sharon L Achilles, Leslie A Meyn, Colleen M Krajewski, Catherine A Chappell, Kavita Vinekar, and Beatrice A Chen. 2023. “Dextromethorphan as a Novel Nonopioid Adjunctive Agent for Pain Control with Medication Abortion: A Randomized Controlled Trial.” Contraception 118 (February): 109908. doi:10.1016/j.contraception.2022.10.010.
    • Harvard:
      Ferguson, G.P. et al. (2023) ‘Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial’, Contraception, 118, p. 109908. doi:10.1016/j.contraception.2022.10.010.
    • Harvard: Australian:
      Ferguson, GP, Achilles, SL, Meyn, LA, Krajewski, CM, Chappell, CA, Vinekar, K & Chen, BA 2023, ‘Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial’, Contraception, vol. 118, p. 109908, viewed 1 June 2023, .
    • MLA 9th Edition:
      Ferguson, Grace P., et al. “Dextromethorphan as a Novel Nonopioid Adjunctive Agent for Pain Control with Medication Abortion: A Randomized Controlled Trial.” Contraception, vol. 118, Feb. 2023, p. 109908. EBSCOhost, https://doi.org/10.1016/j.contraception.2022.10.010.
    • Chicago 17th Edition:
      Ferguson, Grace P, Sharon L Achilles, Leslie A Meyn, Colleen M Krajewski, Catherine A Chappell, Kavita Vinekar, and Beatrice A Chen. “Dextromethorphan as a Novel Nonopioid Adjunctive Agent for Pain Control with Medication Abortion: A Randomized Controlled Trial.” Contraception 118 (February 2023): 109908. doi:10.1016/j.contraception.2022.10.010.
    • Vancouver/ICMJE:
      Ferguson GP, Achilles SL, Meyn LA, Krajewski CM, Chappell CA, Vinekar K, et al. Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial. Contraception [Internet]. 2023 Feb [cited 2023 Jun 1];118:109908. Available from: https://ezproxy.mscc.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=36332661