Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation.

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  • Additional Information
    • Author-Supplied Keywords:
      autograft absolute lymphocyte count
      Autologous peripheral blood hematopoietic stem cell transplantation
      double hit/triple hit lymphoma
    • Subject Terms:
    • Abstract:
      The autograft absolute lymphocyte count (A-ALC) ≥0.5 × 109 cells/kg is a survival prognostic factor for lymphoma patients undergoing autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT). However, the A-ALC has not be tested as prognostic factor against double hit/triple hit lymphomas (DHL/THL). Thus, we set up to investigate if A-ALC is a prognostic factor for overall survival (OS) and progression-free survival (PFS) for DHL/THL post-APBHSCT. From January 2012 until December 2020, we identified 77 DHL/THL patients treated with APBHSCT. All patients required to have the diagnosis of DHL/THL by FISH for rearrangements of MYC, BCL2, and BCL6. With a median follow-up of 20.4 months (range, 0.4-94.5 months), DHL/THL patients infused with A-ALC ≥0.5 x 109 cells/kg experienced superior OS (HR = 0.251, 95%CI 0.117–0.539, p < 0.0004) and PFS (HR = 0.347, 95%CI 0.160–0.753, p < 0.007). Multivariate analysis showed that A-ALC was an independent predictor for OS (HR =0.119, 95%CI 0.030–0.473, p < 0.003) and PFS (HR = 0.400, 95%CI 0.189–0.850, p < 0.02). Our study showed that A-ALC is a prognostic factor for survival in DHL/THL. Our current practice for lymphoma patients is to collect enough stem cell but also A-ALC to improve clinical outcomes post-APBHSCT. [ABSTRACT FROM AUTHOR]
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    • Author Affiliations:
      1Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA
      2Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA
    • Full Text Word Count:
      4919
    • ISSN:
      1042-8194
    • Accession Number:
      10.1080/10428194.2022.2064988
    • Accession Number:
      159584036
  • Citations
    • ABNT:
      PORRATA, L. F. et al. Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. Leukemia & Lymphoma, [s. l.], v. 63, n. 10, p. 2436–2443, 2022. DOI 10.1080/10428194.2022.2064988. Disponível em: https://ezproxy.mscc.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asx&AN=159584036. Acesso em: 2 fev. 2023.
    • AMA 11th Edition:
      Porrata LF, Inwards DJ, Ansell SM, et al. Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. Leukemia & Lymphoma. 2022;63(10):2436-2443. doi:10.1080/10428194.2022.2064988
    • APA 7th Edition:
      Porrata, L. F., Inwards, D. J., Ansell, S. M., Micallef, I. N., Johnston, P. B., Villasboas, J. C., Paludo, J., & Markovic, S. N. (2022). Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. Leukemia & Lymphoma, 63(10), 2436–2443. https://doi.org/10.1080/10428194.2022.2064988
    • Chicago 17th Edition:
      Porrata, Luis F., David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, Jose C. Villasboas, Jonas Paludo, and Svetomir N. Markovic. 2022. “Impact of Autograft-Absolute Lymphocyte Count on Survival in Double/Triple Hit Lymphomas Post-Autologous Stem Cell Transplantation.” Leukemia & Lymphoma 63 (10): 2436–43. doi:10.1080/10428194.2022.2064988.
    • Harvard:
      Porrata, L.F. et al. (2022) ‘Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation’, Leukemia & Lymphoma, 63(10), pp. 2436–2443. doi:10.1080/10428194.2022.2064988.
    • Harvard: Australian:
      Porrata, LF, Inwards, DJ, Ansell, SM, Micallef, IN, Johnston, PB, Villasboas, JC, Paludo, J & Markovic, SN 2022, ‘Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation’, Leukemia & Lymphoma, vol. 63, no. 10, pp. 2436–2443, viewed 2 February 2023, .
    • MLA 9th Edition:
      Porrata, Luis F., et al. “Impact of Autograft-Absolute Lymphocyte Count on Survival in Double/Triple Hit Lymphomas Post-Autologous Stem Cell Transplantation.” Leukemia & Lymphoma, vol. 63, no. 10, Oct. 2022, pp. 2436–43. EBSCOhost, https://doi.org/10.1080/10428194.2022.2064988.
    • Chicago 17th Edition:
      Porrata, Luis F., David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, Jose C. Villasboas, Jonas Paludo, and Svetomir N. Markovic. “Impact of Autograft-Absolute Lymphocyte Count on Survival in Double/Triple Hit Lymphomas Post-Autologous Stem Cell Transplantation.” Leukemia & Lymphoma 63, no. 10 (October 2022): 2436–43. doi:10.1080/10428194.2022.2064988.
    • Vancouver/ICMJE:
      Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, Villasboas JC, et al. Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. Leukemia & Lymphoma [Internet]. 2022 Oct [cited 2023 Feb 2];63(10):2436–43. Available from: https://ezproxy.mscc.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asx&AN=159584036